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Jan-Åke Gustafsson, prof.
Photo: Anders Lindholm, 2007

Jan-Åke Gustafsson, M.D., Ph.D.
Professor, Dept. of Biosciences & Nutrition

E-mail: jan-ake.gustafsson@ki.se

Phone:+46-(0)8-585 837 01
Fax: +46-(0)8-779 87 95

 

Research

World leading research on hormones

Growing knowledge about ERbeta

Studying the role of oestrogen in obesity

CASCADE

Unit for Nuclear Receptor Biology

 

 

CURRICULUM VITAE

Name: Jan-Åke Gustafsson, M.D., Ph.D.

Date of Birth: August 4, 1943

Education:
Ph.D., Dept of Chemistry, Karolinska Institutet, 1968
M.D., Karolinska Institutet, 1971

Career/Academic Appointments:

1964 Bachelor of Medicine, Karolinska Institutet, Stockholm
1971 Associate Professor in Chemistry, Karolinska Institutet
1976 Professor of Chemistry, Karolinska Institutet
1978 Professor of Chemistry, University of Gothenburg
1979 Professor of Medical Nutrition and Chairman of the Dept of Medical Nutrition, Huddinge University Hospital, Karolinska Institutet
2006-2008 Professor of Medical Nutrition and Chairman of the Dept of Biosciences and Nutrition, Karolinska Institutet

Administrative Positions:
1985 Director of the Center for Biotechnology, Huddinge University Hospital, Karolinska Institutet
1987 Founder of KaroBio AB (a campus-situated biotechnology company sponsored by pension and governmental funds with about 80 employees).
2004-present Coordinator for the EU funded CASCADE Network of Excellence

Board Certification:

Has been member of the Faculty Board of the Karolinska Institutet and regularly carries out various assignments for the President’s Office of the Karolinska Institutet.
Awards Committee Member, Endocrine Society, USA 2002-06.
Elected Member of Council (Board) of Endocrine Society, USA, 2007 --

Professional Honors & Recognition

A) International/National/Regional

2008 International Member American Philosophical Society
2005 Descartes Research Prize for excellence in scientific collaborative research
2005 2nd Ernst Knobil Memorial Lecture, San Diego, USA
2004 Medal from Biomedicum Helsinki
2004 Bristol-Meyers Squibb/Mead Johnson Award for Nutrition Research
2003 FEBS Lectureship Datta Award
2002 Commandeur dans l’Ordre des Palmes Académiques
2002 Foreign Honorary Member of the US National Academy of Sciences
2002 Chairman of the Nobel Assembly of the Karolinska Institutet
2002 Fred Conrad Koch Award (Endocrine Soceity USA)
2001 The AF Group Prize for the creation of Novum Research Park
2001 Lorenzini Gold Medal, Lorenzini Foundation
2001 Vice chairman of the Nobel Assembly of the Karolinska Institutet
2000 One of ISI Top 258 Researchers in Biology & Biochemistry
2000 Garvan International Fellow
2000 Burroughs Wellcome Fund Lecture
2000 Foreign Honorary Member of the American Academy of Arts and Sciences
2000 European Medal, British Society for Endocrinology
2000 Curt Nicolin’s Prize for Achievements for the Development of South Stockholm
1999 Medal of the IngaBritt and Arne Lundberg’s Research Foundation
1999 Fogarty Scholar NIH
1998 Adjunct Member of the Nobel Committee of the Karolinska Institutet
1998 The Söderberg Prize in Medicine
1998 Member of the Swedish Academy of Engineering Sciences
1997 Member of the Swedish Academy of Sciences
1994 Gregory Pincus Medal and Award, Worcester Foundation
1992 Keith Harris Lecture, Australian Endocrine Society, Adelaide
1992 The Anders Jahre Prize, Oslo
1992 Medal from Collège de France, Paris
1990 Honorary Member of the American Society for Biochemistry and Molecular Biology
1986 Honorary Member of the Japanese Biochemical Society
1986 Member of the Nobel Assembly of the Karolinska Institutet
1983 The Fernström Prize of the Karolinska Institutet
1982 The Svedberg Prize in Chemistry, Stockholm

B) University

2008 EMD Serono President’s Distinguished Lecture: “Estrogen Receptor-Beta and Reproduction”. Annual Meeting of the Society for Gynecological Investigation, San Diego.
2008 Honorary Professor at the Beijing Normal University
2008 Honorary doctorate in Medicinal and Pharmaceutical Chemistry at the University of Milan
2007 Honorary Professor at the University of Chongquin, China
2007 Honorary doctorate in Medicinal and Pharmaceutical Chemistry at the University of Milan
2004 Guest Professor at the University of Science and Technology of China, Hefei
2003 J.G. Moore Visiting Professor, UCLA, USA
2003 Marius Tausk Visiting Professor at the Leiden University Medical Centre (LUMC)
2003 McDowell Lecture in Physiology, King’s College, London, U.K.
2002 Burroughs Wellcome Fund Visiting Professor in the Basic Medical Sciences at the University of Texas Medical Branch School of Medicine
2000 Center for Bioenvironmental Research Distinguished Visiting Professor, Tulane University, New Orleans
1995 Sterling Visiting Professor, University of Pennsylvania, Philadelphia
1991 Consultant to The Rockefeller University Hospital
1987 Adjunct Full Professor at the Department of Cell Biology, Baylor College of
Medicine, Houston, Texas

Patents, Softwares, Databases
Estrogen receptor β-based hypertension treatment and assay.
Patent No: GB 2374412

Estrogen receptors and their ligands for treating obesity and lowering lipoprotein levels
Patent No: US 2002151732

Cloning, characterization and pharmaceutical use of a mammalian nuclear receptor coactivator RAP250.
Patent No: US 2002151477

Estrogen receptor beta (ERβ) agonists for use in cancer treatment.
Patent No: GB 2361642

Method of estrogen receptor isoform detection via immunostaining and correlation with breast cancer.
Patent No: GB 2361769

Cancer treatment and prognosis involving HES-1 protein.
Patent No: WO 2001062792

Estrogen receptor β agonists and antagonists for the treatment of growth or bone mineral density disorders.
Patent No: WO 2000076529

Osteoporosis treatment with an estrogen receptor β antagonists.
Patent No: WO 2000061230

Estrogen receptor ER β ligands for Vasculoprotectors.
Patent No: WO 2000001716

Differential activation of estrogen receptors ERα and ERβ at ap1 sites.
Patent No: WO 9911760

Molecular cloning, cDNA sequences, and therapeutic uses of mammalian estrogen receptorβ.
Patent No: WO 9709348

OR-1 orphan receptors belonging to the nuclear receptor family.
Patent No: WO 605300

Other Activities:
Has participated in the supervision of 98 Ph.D. students to the presentation of their thesis.
Has supervised 129 postdocs/visiting scientists.


BIBLIOGRAPHY

Has over 1300 peer-reviewed publications. Can be sent upon request.
PDF-dokument of: selected publications
Has so far been cited 59 941 times. (ISI HiglyCited.com)

Top 10 publications:

1. Ö. Wrange and J.-Å. Gustafsson: Separation of the hormone- and DNA-binding sites of the hepatic glucocorticoid receptor by means of proteolysis. J. Biol. Chem. 253, 856-865, 1978.

FIRST DEMONSTRATION OF DOMAIN STRUCTURE OF A NUCLEAR RECEPTOR

2. Ö. Wrange, J. Carlstedt-Duke and J.-Å. Gustafsson: Purification of the glucocorticoid receptor from rat liver cytosol. J. Biol. Chem. 254, 9284-9290, 1979.

FIRST PURIFICATION OF A NUCLEAR RECEPTOR TO HOMOGENEITY

3. F. Payvar, Ö. Wrange, J. Carlstedt-Duke, S. Okret, J.-Å. Gustafsson and K.R. Yamamoto: Purified glucocorticoid receptors bind selectively in vitro to a cloned DNA fragment whose transcription is regulated by glucocorticoids in vivo. Proc. Natl. Acad. Sci. USA 78, 6628-6632, 1981.

FIRST DEMONSTRATION OF SPECIFIC BINDING OF A NUCLEAR RECEPTOR TO DNA

4. R. Miesfeld, S. Okret, A.-C. Wikström, Ö. Wrange, J.-Å. Gustafsson and K. Yamamoto: Characterization of a steroid receptor gene and mRNA in wild-type and mutant cells. Nature 312, 779-781, 1984.

FIRST CLONING OF A NUCLEAR RECEPTOR cDNA

5. T. Härd, E. Kellenbach, R. Boelens, B. A. Maler, K. Dahlman, L. P. Freedman, J. Carlstedt-Duke, K. R. Yamamoto, J.-Å. Gustafsson, and R. Kaptein: Solution structure of the glucocorticoid receptor DNA-binding domain. Science, 249, 157-160, 1990.

FIRST 3-D STRUCTURE OF A NUCLEAR RECEPTOR DOMAIN (THE DBD)

6. M. Göttlicher, E. Widmark, Q. Li, and J.-Å. Gustafsson: Fatty acids activate a chimera of the clofibric acid-activated receptor and the glucocorticoid receptor. Proc.Natl.Acad.Sci. USA, 89, 4653-4657, 1992.

FIRST DESCRIBED ACTIVATORS OF AN ORPHAN NUCLEAR RECEPTOR (FATTY ACIDS FOR PPARa)

7. M. Teboul, E. Enmark, Q. Li, A.C. Wikström, M. Pelto-Huikko, and J.-Å. Gustafsson: OR-1, a member of the nuclear receptor superfamily that interacts with the 9-cis-retinoic acid receptor. Proc. Natl. Acad. Sci. USA, 92, 2096-2100, 1995.

DISCOVERY OF LXRß

8. G.G.J.M. Kuiper, E. Enmark, M. Pelto-Huikko, S. Nilsson, and J.-Å. Gustafsson: Cloning of a novel estrogen receptor expressed in rat prostate and ovary. Proc.Natl.Acad.Sci. USA, 93, 5925-5930, 1996.

DISCOVERY OF THE 2ND ESTROGEN RECEPTOR, ERß, CAUSING A PARADIGM SHIFT IN OUR UNDERSTANDING OF ESTROGEN SIGNALING

9. A.M. Brzozowski, A.C.W. Pike, Z. Dauter, R.E. Hubbard, T. Bonn, O. Engström, L. Öhman, G.L. Greene, J.-Å. Gustafsson and M. Carlquist: Insights into the molecular basis of agonism and antagonism in the oestrogen receptor as revealed by complexes with 17ß-oestradiol and raloxifene. Nature, 389, 753-758, 1997.

DISCOVERY OF THE MOLECULAR MECHANISM OF ANTAGONISM (HELIX 12 PERTURBATION) WITHIN NUCLEAR RECEPTORS

10. Z. Weihua, S. Mäkelä, L. C. Andersson, S. Salmi, S. Saji, J. I. Webster, E. V. Jensen, S. Nilsson, M. Warner, and J.-Å. Gustafsson: A role for estrogen receptor in the regulation of growth of the ventral prostate. Proc.Natl.Acad.Sci. USA, 98, 6330-6335, 2001.

DISCOVERY OF THE REGULATORY ROLE OF ERß IN THE GROWTH OF THE PROSTATE

Grant History (PDF)

Lectures, Courses, Web-based Education

 

PROFESSIONAL SERVICE

Peer Review Groups/Grant Study Sections

2007 Member of the LTA (LAM Treatment Alliance) SAB (Scientific Advisory Board, Boston
2007 Member of the IRB Barcelona External Advisory Board
2007 Member of the selection committee for The King Faisal International Prize
in Science
2005--2007 Member of the International Academic Advisory Committee (IAAC), Hefei,
Peoples’s Republic of China
Since 1995 Member of the International Advisory Board of the WHO Center in Oulu

Has had several appointments at and tasks for The Swedish Board for Planning and Coordination of Research, The Swedish Medical Research Council, The Swedish Cancer Society, The Swedish Environmental Protection Agency and The Swedish Fund for Strategic Research

Has participated in several international reviewing panels, e.g.:

1995 Chairman of a board evaluating the Center for Biotechnology, University of Oslo
1994 Member of a board evaluating the Center for Biotechnology, Helsinki
1991 As chairman of a board evaluating the Norwegian Biotechnology Program

Journal Service

Member, currently and/or previously, of the editorial board or similar position in Steroids, The Journal of Steroid Biochemistry and Molecular Biology, Molecular Endocrinology, Breast Cancer Research and Treatment, The Prostate, Anticancer Research, Japanese Journal of Cancer Research, Journal of Molecular Medicine, Molecular Pharmacology, the International Journal of Oncology and Experimental Biology and Medicine.

Professional Organizations
Meeting Planning/Participation

Regular co-organizer of The Summer School of Signal Transduction held in Spetsai, Greece, every two years since 1990.

2007 Spetses Summer School on Nuclear Receptor Signalling: From
Molecular Mechanisms to Integrative Physiology, Island of Spetses, Greece
2006 "Nuclear Receptors 2006" An International Symposium arranged by the dept. of Biosciences and Nutrition, Karolinska Institutet.
2004 “Nuclear Receptors 2004” An International Symposium arranged by the Center for Biotechnology (CBT), Karolinska Institutet
2003 FEBS Advanced Study Institute, International Summer School on "From Transcription to Physiology: Regulation of Gene Expression and Protein Function in an Integrated Context", Island of Spetses, Greece.
2003 Nobel Conference No 40: "Transcriptional control of lipid homeostasis"
2003 EMBO Conference, Biology of Nuclear Receptors, Villefranche-sur-Mer, France.
2002 "Nuclear Receptors 2002", A joint International Symposium arranged by the Center for Biotechnology (CBT), Karolinska Institutet in collaboration with the Summer University of Southern Stockholm.
2000 10th CBT symposium “Nuclear receptors in health and disease”.
1999 Nobel symposium “Estrogens and women’s health – benefit or threat?”
1997 9th CBT Symposium “Steroid and orphan nuclear receptors”.
1995 7th CBT Symposium “Nuclear orphan receptors: Novel regulators in physiology and pathology”.
1993 5th CBT Symposium “Intracellular hormone receptors and ligan-dependent transcriptional regulation”.
1988 2nd CBT Symposium “The steroid/thyroid hormone receptor family and gene regulation”.
1983 Nobel symposium “Steroid hormone receptors: Structure and function”.

 

 

 

 

Page updated by Marie Franzén 2009-01-15


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