Anders Lindholm, 2007
Gustafsson, M.D., Ph.D.
Professor, Dept. of Biosciences & Nutrition
Phone:+46-(0)8-585 837 01
Fax: +46-(0)8-779 87 95
leading research on hormones
knowledge about ERbeta
the role of oestrogen in obesity
for Nuclear Receptor Biology
Jan-Åke Gustafsson, M.D., Ph.D.
Date of Birth:
August 4, 1943
Ph.D., Dept of Chemistry,
Karolinska Institutet, 1968
M.D., Karolinska Institutet, 1971
1964 Bachelor of Medicine,
Karolinska Institutet, Stockholm
1971 Associate Professor in Chemistry, Karolinska Institutet
1976 Professor of Chemistry, Karolinska Institutet
1978 Professor of Chemistry, University of Gothenburg
1979 Professor of Medical Nutrition and Chairman of the Dept of Medical
Nutrition, Huddinge University Hospital, Karolinska Institutet
2006-2008 Professor of Medical Nutrition and Chairman of the Dept of Biosciences
and Nutrition, Karolinska Institutet
1985 Director of the
Center for Biotechnology, Huddinge University Hospital, Karolinska Institutet
1987 Founder of KaroBio AB (a campus-situated biotechnology company sponsored
by pension and governmental funds with about 80 employees).
2004-present Coordinator for the EU funded CASCADE Network of Excellence
Has been member of
the Faculty Board of the Karolinska Institutet and regularly carries out
various assignments for the President’s Office of the Karolinska
Awards Committee Member, Endocrine Society, USA 2002-06.
Elected Member of Council (Board) of Endocrine Society, USA, 2007 --
Honors & Recognition
2008 International Member American Philosophical Society
Patents, Softwares, Databases
2005 Descartes Research Prize for excellence in scientific
2005 2nd Ernst Knobil Memorial Lecture, San Diego, USA
2004 Medal from Biomedicum Helsinki
2004 Bristol-Meyers Squibb/Mead Johnson Award for Nutrition Research
2003 FEBS Lectureship Datta Award
2002 Commandeur dans l’Ordre des Palmes Académiques
2002 Foreign Honorary Member of the US National Academy of Sciences
2002 Chairman of the Nobel Assembly of the Karolinska Institutet
2002 Fred Conrad Koch Award (Endocrine Soceity USA)
2001 The AF Group Prize for the creation of Novum Research Park
2001 Lorenzini Gold Medal, Lorenzini Foundation
2001 Vice chairman of the Nobel Assembly of the Karolinska Institutet
2000 One of ISI Top 258 Researchers in Biology & Biochemistry
2000 Garvan International Fellow
2000 Burroughs Wellcome Fund Lecture
2000 Foreign Honorary Member of the American Academy of Arts and Sciences
2000 European Medal, British Society for Endocrinology
2000 Curt Nicolin’s Prize for Achievements for the Development of
1999 Medal of the IngaBritt and Arne Lundberg’s Research Foundation
1999 Fogarty Scholar NIH
1998 Adjunct Member of the Nobel Committee of the Karolinska Institutet
1998 The Söderberg Prize in Medicine
1998 Member of the Swedish Academy of Engineering Sciences
1997 Member of the Swedish Academy of Sciences
1994 Gregory Pincus Medal and Award, Worcester Foundation
1992 Keith Harris Lecture, Australian Endocrine Society, Adelaide
1992 The Anders Jahre Prize, Oslo
1992 Medal from Collège de France, Paris
1990 Honorary Member of the American Society for Biochemistry and Molecular
1986 Honorary Member of the Japanese Biochemical Society
1986 Member of the Nobel Assembly of the Karolinska Institutet
1983 The Fernström Prize of the Karolinska Institutet
1982 The Svedberg Prize in Chemistry, Stockholm
2008 EMD Serono President’s Distinguished Lecture: “Estrogen
Receptor-Beta and Reproduction”. Annual Meeting of the Society for
Gynecological Investigation, San Diego.
2008 Honorary Professor at the Beijing Normal University
2008 Honorary doctorate in Medicinal and Pharmaceutical Chemistry at the
University of Milan
2007 Honorary Professor at the University of Chongquin, China
2007 Honorary doctorate in Medicinal and Pharmaceutical Chemistry at the
University of Milan
2004 Guest Professor at the University of Science and Technology of China,
2003 J.G. Moore Visiting Professor, UCLA, USA
2003 Marius Tausk Visiting Professor at the Leiden University Medical
2003 McDowell Lecture in Physiology, King’s College, London, U.K.
2002 Burroughs Wellcome Fund Visiting Professor in the Basic Medical Sciences
at the University of Texas Medical Branch School of Medicine
2000 Center for Bioenvironmental Research Distinguished Visiting Professor,
Tulane University, New Orleans
1995 Sterling Visiting Professor, University of Pennsylvania, Philadelphia
1991 Consultant to The Rockefeller University Hospital
1987 Adjunct Full Professor at the Department of Cell Biology, Baylor
Medicine, Houston, Texas
Estrogen receptor β-based hypertension treatment and assay.
Patent No: GB 2374412
Estrogen receptors and their ligands for treating obesity
and lowering lipoprotein levels
Patent No: US 2002151732
Cloning, characterization and pharmaceutical use of a
mammalian nuclear receptor coactivator RAP250.
Patent No: US 2002151477
Estrogen receptor beta (ERβ) agonists for use in
Patent No: GB 2361642
Method of estrogen receptor isoform detection via immunostaining
and correlation with breast cancer.
Patent No: GB 2361769
Cancer treatment and prognosis involving HES-1 protein.
Patent No: WO 2001062792
Estrogen receptor β agonists and antagonists for
the treatment of growth or bone mineral density disorders.
Patent No: WO 2000076529
Osteoporosis treatment with an estrogen receptor β
Patent No: WO 2000061230
Estrogen receptor ER β ligands for Vasculoprotectors.
Patent No: WO 2000001716
Differential activation of estrogen receptors ERα
and ERβ at ap1 sites.
Patent No: WO 9911760
Molecular cloning, cDNA sequences, and therapeutic uses
of mammalian estrogen receptorβ.
Patent No: WO 9709348
OR-1 orphan receptors belonging to the nuclear receptor
Patent No: WO 605300
Has participated in
the supervision of 98 Ph.D. students to
the presentation of their thesis.
Has supervised 129 postdocs/visiting scientists.
Has over 1300 peer-reviewed
publications. Can be sent upon request.
PDF-dokument of: selected
Has so far been cited 59 941 times. (ISI HiglyCited.com)
Top 10 publications:
Wrange and J.-Å. Gustafsson: Separation of the hormone- and DNA-binding
sites of the hepatic glucocorticoid receptor by means of proteolysis.
J. Biol. Chem. 253, 856-865, 1978.
OF DOMAIN STRUCTURE OF A NUCLEAR RECEPTOR
2. Ö. Wrange,
J. Carlstedt-Duke and J.-Å. Gustafsson: Purification of the glucocorticoid
receptor from rat liver cytosol. J. Biol. Chem. 254, 9284-9290, 1979.
OF A NUCLEAR RECEPTOR TO HOMOGENEITY
3. F. Payvar, Ö.
Wrange, J. Carlstedt-Duke, S. Okret, J.-Å. Gustafsson and K.R. Yamamoto:
Purified glucocorticoid receptors bind selectively in vitro to a cloned
DNA fragment whose transcription is regulated by glucocorticoids in vivo.
Proc. Natl. Acad. Sci. USA 78, 6628-6632, 1981.
OF SPECIFIC BINDING OF A NUCLEAR RECEPTOR TO DNA
4. R. Miesfeld, S.
Okret, A.-C. Wikström, Ö. Wrange, J.-Å. Gustafsson and
K. Yamamoto: Characterization of a steroid receptor gene and mRNA in wild-type
and mutant cells. Nature 312, 779-781, 1984.
FIRST CLONING OF
A NUCLEAR RECEPTOR cDNA
5. T. Härd, E.
Kellenbach, R. Boelens, B. A. Maler, K. Dahlman, L. P. Freedman, J. Carlstedt-Duke,
K. R. Yamamoto, J.-Å. Gustafsson, and R. Kaptein: Solution structure
of the glucocorticoid receptor DNA-binding domain. Science, 249, 157-160,
FIRST 3-D STRUCTURE
OF A NUCLEAR RECEPTOR DOMAIN (THE DBD)
6. M. Göttlicher,
E. Widmark, Q. Li, and J.-Å. Gustafsson: Fatty acids activate a
chimera of the clofibric acid-activated receptor and the glucocorticoid
receptor. Proc.Natl.Acad.Sci. USA, 89, 4653-4657, 1992.
FIRST DESCRIBED ACTIVATORS OF AN ORPHAN NUCLEAR RECEPTOR (FATTY ACIDS
7. M. Teboul, E. Enmark,
Q. Li, A.C. Wikström, M. Pelto-Huikko, and J.-Å. Gustafsson:
OR-1, a member of the nuclear receptor superfamily that interacts with the
9-cis-retinoic acid receptor. Proc. Natl. Acad. Sci. USA, 92, 2096-2100,
DISCOVERY OF LXRß
8. G.G.J.M. Kuiper,
E. Enmark, M. Pelto-Huikko, S. Nilsson, and J.-Å. Gustafsson: Cloning
of a novel estrogen receptor expressed in rat prostate and ovary. Proc.Natl.Acad.Sci.
USA, 93, 5925-5930, 1996.
DISCOVERY OF THE 2ND
ESTROGEN RECEPTOR, ERß, CAUSING A PARADIGM SHIFT IN OUR UNDERSTANDING
OF ESTROGEN SIGNALING
9. A.M. Brzozowski,
A.C.W. Pike, Z. Dauter, R.E. Hubbard, T. Bonn, O. Engström, L. Öhman,
G.L. Greene, J.-Å. Gustafsson and M. Carlquist: Insights into the
molecular basis of agonism and antagonism in the oestrogen receptor as
revealed by complexes with 17ß-oestradiol and raloxifene. Nature,
389, 753-758, 1997.
DISCOVERY OF THE MOLECULAR
MECHANISM OF ANTAGONISM (HELIX 12 PERTURBATION) WITHIN NUCLEAR RECEPTORS
10. Z. Weihua, S.
Mäkelä, L. C. Andersson, S. Salmi, S. Saji, J. I. Webster, E.
V. Jensen, S. Nilsson, M. Warner, and J.-Å. Gustafsson: A role for
estrogen receptor in the regulation of growth of the ventral prostate.
Proc.Natl.Acad.Sci. USA, 98, 6330-6335, 2001.
DISCOVERY OF THE REGULATORY
ROLE OF ERß IN THE GROWTH OF THE PROSTATE
Grant History (PDF)
Lectures, Courses, Web-based
Groups/Grant Study Sections
2007 Member of the
LTA (LAM Treatment Alliance) SAB (Scientific Advisory Board, Boston
2007 Member of the IRB Barcelona External Advisory Board
2007 Member of the selection committee for The King Faisal International
2005--2007 Member of the International Academic Advisory Committee (IAAC),
Peoples’s Republic of China
Since 1995 Member of the International Advisory Board of the WHO Center
Has had several appointments at and tasks for The Swedish Board for Planning
and Coordination of Research, The Swedish Medical Research Council, The
Swedish Cancer Society, The Swedish Environmental Protection Agency and
The Swedish Fund for Strategic Research
in several international reviewing panels, e.g.:
1995 Chairman of
a board evaluating the Center for Biotechnology, University of Oslo
1994 Member of a board evaluating the Center for Biotechnology, Helsinki
1991 As chairman of a board evaluating the Norwegian Biotechnology Program
Member, currently and/or previously, of the editorial board or similar
position in Steroids, The Journal of Steroid Biochemistry and Molecular
Biology, Molecular Endocrinology, Breast Cancer Research and Treatment,
The Prostate, Anticancer Research, Japanese Journal of Cancer Research,
Journal of Molecular Medicine, Molecular Pharmacology, the International
Journal of Oncology and Experimental Biology and Medicine.
of The Summer School of Signal Transduction held in Spetsai, Greece, every
two years since 1990.
School on Nuclear Receptor Signalling: From
Molecular Mechanisms to Integrative Physiology, Island of Spetses,
Receptors 2006" An International Symposium arranged by the dept.
of Biosciences and Nutrition, Karolinska Institutet.
2004” An International Symposium arranged by the Center for Biotechnology
(CBT), Karolinska Institutet
Study Institute, International Summer School on "From Transcription
to Physiology: Regulation of Gene Expression and Protein Function
in an Integrated Context", Island of Spetses, Greece.
No 40: "Transcriptional control of lipid homeostasis"
Biology of Nuclear Receptors, Villefranche-sur-Mer, France.
Receptors 2002", A joint International Symposium arranged by
the Center for Biotechnology (CBT), Karolinska Institutet in collaboration
with the Summer University of Southern Stockholm.
||10th CBT symposium
“Nuclear receptors in health and disease”.
“Estrogens and women’s health – benefit or threat?”
||9th CBT Symposium
“Steroid and orphan nuclear receptors”.
||7th CBT Symposium
“Nuclear orphan receptors: Novel regulators in physiology and
||5th CBT Symposium
“Intracellular hormone receptors and ligan-dependent transcriptional
||2nd CBT Symposium
“The steroid/thyroid hormone receptor family and gene regulation”.
“Steroid hormone receptors: Structure and function”.